Objective. To investigate the relationship between abdominal adipose tissue distribution, Ã?²-cell function, and insulin sensitivity (IS)\nin a Chinese population. Methods. One hundred and eighty-eight healthy subjects (healthy group), 239 with normal glucose, and\n1~4 abnormal metabolic traits (metabolic dysfunction group, MD group) and 125 with hyperglycemia (hyperglycemia group) were\nstudied. HOMA-IR, HOMA-B, Matsuda index, early- (I0ââ?¬â??30/G0ââ?¬â??30) and late-phase (I30ââ?¬â??120/G30ââ?¬â??120) insulin responses and the\ncorresponding disposition indexes (DI) were calculated. The area of abdominal subcutaneous adipose tissue (ASAT) and visceral\nadipose tissue (VAT) was measured and the ratio of ASAT to VAT (SVR) was calculated. Results. SVR was correlated positively\nwith Matsuda index in healthy, MD, and hyperglycemia groups, and inversely with HOMA-IR. SVR positively related with both\nearly- and late-phase DI in the healthy group only. In the healthy group, the hyperbolas of I0ââ?¬â??30/G0ââ?¬â??30 and I30ââ?¬â??120/G30ââ?¬â??120 versus\nMatsuda index in the highest quarter of SVR were significantly right shifted compared to those in the lowest (both P < 0 05).\nConclusions. In healthy adults, higher SVR was a protective factor for Ã?²-cell function and IS, while in those with glucometabolic\nabnormality, higher SVR contributed to a relative better IS, indicating SVR is possible to be an early predicator of type 2\ndiabetes development.
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